Faculty


Scheck

Rebecca A. Scheck

Department of Chemistry
Pearson Chemistry Laboratory
62 Talbot Avenue
Tufts University 
Medford, MA 02155 

Office: P-100X

Tel: 617-627-0450  Fax: 617-627-3443

E-mail: rebecca.scheck@tufts.edu

Research Homepage


Current Appointments

 

Assistant Professor of Chemistry, Department of Chemistry

 

Education

 

B.A., 2004, Columbia University, New York, NY
Ph.D, 2008, University of California, Berkeley, CA
NIH Ruth L. Kirschstein Postdoctoral Fellow, 2008-11, Yale University, New Haven CT

 

Research Interests

 

Bioorganic Chemistry and Chemical Biology.  A significant frontier in chemical biology lies in the ability to develop new, selective chemical transformations that transpire at mild temperatures amidst many other reactive species and in parallel with the countless transformations that occur inside of a living cell. Research in the Scheck laboratory focuses on the invention and application of encodable, bioorthogonal chemical strategies. These tools will be used to report on inducible changes in protein function in living cells.  Current efforts in the lab fall into two broad categories: 1) The development of new chemical methods that are used to study complex posttranslational modification networks and 2) The study of native and unnatural posttranslational modifications to provide valuable chemical and synthetic biology tools.

 

Selected Recent Publications

 

“A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication,” Kotewicz, Kristin M., Ramabhadran, Vinay, Sjoblom, Nicole, Vogel, Joseph P., Haenssler, Eva, Zhang, Mengyun, Behringer, Jessica, Scheck, Rebecca A., and Isberg, Ralph R., Cell Host & Microbe, 201721, 169-181.

 

“Growth Factor Identity Is Encoded by Discrete Coiled-Coil Rotamers in the EGFR Juxtamembrane Region,” Doerner, Amy, Scheck, Rebecca, and Schepartz, Alanna, Chemistry & Biology, 201522, 776-784. 


"Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation", R. A. Scheck, M. A. Lowder, J. S. Appelbaum, and A. Schepartz, ACS Chem. Bio., 2012, 7, 1367-1376.


"Identification of Highly Reactive Sequences For PLP-Mediated Bioconjugation Using a Combinatorial Peptide Library", L. S. Witus, T. Moore, B. W. Thuronyi, A. P. Esser-Kahn, R. A. Scheck, A. T. Iavarone,  and M. B. Francis, J. Amer. Chem. Soc, 2010, 132, 16812–16817.


"Optimization of a biomimetic transamination reaction", R. A. Scheck, M. T. Dedeo, A. T. Iavarone, and M. B. Francis, J. Amer. Chem. Soc., 2008, 130, 11762–11770.


"Regioselective labeling of antibodies through N-terminal transamination", R. A. Scheck and M. B. Francis, ACS Chem. Bio., 2007, 2, 247-251.


"N-terminal protein modification through a biomimetic transamination reaction", J. M. Gilmore†, R. A. Scheck†, N. S. Joshi, and M. B. Francis, Ang.Chem.(Int.Ed.), 2006, 45, 5307-5311. † Equal Contribution