Bioorganic,
Biophysical, & Chemical Biology
Discovery of chemical genetics agents and their use
in understanding the molecular biology of human disease. Design, selection
and evolution of ligands to target biological pathways involved in human
disease. Use of peptide libraries to identify molecules with defined
function and explore their nature using synthesis,
biophysical chemistry, cell biology and genetics. Exploration of
structure/function relationships, peptidomimetic design, and nontraditional
modes of drug action such as inhibition of protein-protein interactions and
pharmacological chaperoning.
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